Theses

Open Topics

Microstructure-mechanics correlation in gray matter structures of the human brain

Supervisor: Nina Reiter

Starting Date: open

Temperature sensitivity of the mechanical properties of spinal cord by nanoindentation

Supervisor: Oskar Neumann

Starting Date: open

 

Finished Theses

Master Thesis

  • Entwicklung einer Softwarelösung zur Erstellung von 3D-Netzen von Zellstrukturen aus mikroskopischen Bilddaten
  • Mechanical and microstructural characterization of the murine extraorbital lacrimal gland
  • Quantification of Stiffness Gradients in Porcine Brain Tissue and Alginate-based Hydrogels Through Indentation Experiments
  • Effects of cell proliferation on the mechanical behaviour of alginate-based hydrogels
  • Poro-viscoelastic modeling and simulation of regional brain tissue properties under different loading conditions
  • Computational modeling and simulation of spatio-temporal COVID-19 outbreak dynamics in Germany
  • Quantitative analysis of cellular and extracellular components of human brain tissue through Enzyme-Linked Immunosorbent Assays (ELISA)
  • Experimental analysis of the effects of cell differentiation and proliferation on the mechanical properties of cell-laden alginate-based hydrogels
  • Insights into the Microstructural Origin of Brain Viscoelasticity
  • Multi-Modal Mechanical Analysis and Inverse Parameter Identification of Human Brain Tissue
  • Analysis of the individual contributions of cells and matrix material on the mechanical properties of alginate-based hydrogels
  • Computational Analysis of Wrinkling Modes in the Developing Brain
  • A systematic study towards the rheology of healthy and diseased human brain tissue and its correlation with the underlying microstructure
  • A continuum based model to investigate geometrical instabilities under different modes of compression
  • Mechanical Characterization of Human Brain Tissue
  • Investigation of the influence of myelination on the mechanical properties of brain tissue using Abaqus

Project Thesis

  • Validation of a numerical model for human brain development via microscope images and analytical predictions
  • Experimental and computational analysis of geometrical effects of cortical folding
  • Numerical Investigations towards the Hyper- and Viscoelasticity of Human Brain Tissue
  • Understanding how our brain folds: growth-induced geometric instabilities in hyperelastic bilayers
  • Computational aspects of growth-induced geometric instabilities: a comparison of linear and quadratic finite elements

Bachelor Thesis

  • Rheological and Microstructural Characterization of Human Brain Organoids
  • Quantifying microstructural components of human brain tissue through histological and immunohistochemical staining
  • Mechanical analysis of oxidized alginate-based hydrogels as substitute materials for brain tissue
  • Implementation of a Turing reaction-diffusion system to elucidate brain folding
  • Regional, directional, and species-dependent mechanical properties of brain tissue
  • Experimental and computational investigation of buckling instabilities in thin polymer films as a model problem for brain folding